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Shapiro MD Studies

EFFECTIVE: July 15th, 2021

Source and Studies

Shapiro MD’s hair care formulations were developed by dermatologists and backed by science. This list includes some of the published medical research and scientific documentation supporting many of the ingredients we deploy at Shapiro MD.

Bazzano G, Terezakis N, Galen W. Topical tretinoin for hair growth promotion. J Am Acad Dermatol. 1986;15(4):880-893. doi:10.1016/s0190-9622(86)80024-x

Olsen E, Dunlap F, Funicella T et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2002;47(3):377-385. doi:10.1067/mjd.2002.124088

Hajheydari Z, Akbari J, Saeedi M, Shokoohi L. Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol. 2009 Jan-Feb;75(1):47-51. doi: 10.4103/0378-6323.45220. PMID: 19172031.

Chandrashekar BS, Nandhini T, Vasanth V, Sriram R, Navale S. Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride. Indian Dermatol Online J. 2015;6(1):17-20. doi:10.4103/2229-5178.148925

Lucky AW, Piacquadio DJ, Ditre CM, et al. A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J Am Acad Dermatol. 2004;50(4):541-553. doi:10.1016/j.jaad.2003.06.014

Ahmed S. Abdelshafy, M.D. A, Almabrouk, M.Sc. M. Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia. Med J Cairo Univ. 2020;88(6):1017-1022. doi:10.21608/mjcu.2020.110836

Abdel‐Raouf H, Aly U, Medhat W, Ahmed S, Abdel‐Aziz R. A novel topical combination of minoxidil and spironolactone for androgenetic alopecia: Clinical, histopathological, and physicochemical study. Dermatol Ther. 2020;34(1). doi:10.1111/dth.14678

Dallob AL, Sadick NS, Unger W, et al. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. J Clin Endocrinol Metab. 1994;79(3):703-706. doi:10.1210/jcem.79.3.8077349

Whiting DA, Olsen EA, Savin R, et al. Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. Eur J Dermatol. 2003;13(2):150-160.

Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, Price VH, Van Neste D, Roberts JL, Hordinsky M, Shapiro J, Binkowitz B, Gormley GJ. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol. 1998 Oct;39(4 Pt 1):578-89. doi: 10.1016/s0190-9622(98)70007-6. PMID: 9777765.

Shi, Yuan-Pei (1986). Topical Minoxidil in the Treatment of Alopecia Areata and Male-Pattern Alopecia. Archives of Dermatology, 122(5), 506–. doi:10.1001/archderm.1986.01660170030011

Olsen EA, Whiting D, Bergfeld W, et al. A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol. 2007;57(5):767-774. doi:10.1016/j.jaad.2007.04.012

Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. J Am Acad Dermatol. 2017;77(1):136-141.e5. doi:10.1016/j.jaad.2017.02.054

Schmalenberg K. et al. Restoring dry, damaged hair with a novel natural wheat protein and wheat germ oil– containing shampoo and conditioner line. J Am Acad Dermatol. 2010;62(3):AB77. doi:10.1016/j.jaad.2009.11.320

Rele AS, Mohile RB. Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage. J Cosmet Sci. 2003;54(2):175-192.

Ortiz-Avila O, Sámano-García CA, Calderón-Cortés E, et al. Dietary avocado oil supplementation attenuates the alterations induced by type I diabetes and oxidative stress in electron transfer at the complex II-complex III segment of the electron transport chain in rat kidney mitochondria. J Bioenerg Biomembr. 2013;45(3):271-287. doi:10.1007/s10863-013-9502-3

Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med. 2014;2014:549721. doi:10.1155/2014/549721

Vardy D, Cohen A, Tchetov T, Medvedovsky E, Biton A. A double-blind, placebo-controlled trial of anAloe vera (A. barbadensis)emulsion in the treatment of seborrheic dermatitis. Journal of Dermatological Treatment. 1999;10(1):7-11. doi:10.3109/09546639909055904

Yu S, Rogers QR, Morris JG. Effect of low levels of dietary tyrosine on the hair colour of cats. J Small Anim Pract. 2001;42(4):176-180. doi:10.1111/j.1748-5827.2001.tb01798.x

Daulatabad D, Singal A, Grover C, Chhillar N. Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B12, and Folic Acid in Patients with Premature Canities. Int J Trichology. 2017;9(1):19-24. doi:10.4103/ijt.ijt_79_16

Goluch-Koniuszy ZS. Nutrition of women with hair loss problem during the period of menopause. Prz Menopauzalny. 2016;15(1):56-61. doi:10.5114/pm.2016.58776

Kil MS, Kim CW, Kim SS. Analysis of serum zinc and copper concentrations in hair loss. Ann Dermatol. 2013;25(4):405-409. doi:10.5021/ad.2013.25.4.405

Nyenwe E, Dagogo-Jack S. Iodine Deficiency Disorders in the Iodine-Replete Environment. Am J Med Sci. 2009;337(1):37-40. doi:10.1097/maj.0b013e31817baaf0

Piato AL, Detanico BC, Linck VM, Herrmann AP, Nunes DS, Elisabetsky E. Anti-stress effects of the "tonic" Ptychopetalum olacoides (Marapuama) in mice. Phytomedicine. 2010;17(3-4):248-253. doi:10.1016/j.phymed.2009.07.001

El-Garf, A., Mohie, M. & Salah, E. Trichogenic effect of topical ketoconazole versus minoxidil 2% in female pattern hair loss: a clinical and trichoscopic evaluation. biomed dermatol 3, 8 (2019). https://doi.org/10.1186/s41702-019-0046-y

Wang S, Meng D, Wang S, Zhang Z, Yang R, Zhao W. Modification of wheat gluten for improvement of binding capacity with keratin in hair. R Soc Open Sci. 2018;5(2):171216. Published 2018 Feb 7. doi:10.1098/rsos.171216

Christina Beer, Simon Wood, Robert H. Veghte, "A Clinical Trial to Investigate the Effect of Cynatine HNS on Hair and Nail Parameters", The Scientific World Journal, vol. 2014, Article ID 641723, 6 pages, 2014. https://doi.org/10.1155/2014/641723

Faria P, Camargo L, Carvalho R, Paludetti L, Velasco M, Gama R. Hair Protective Effect of Argan Oil (Argania spinosa Kernel Oil) and Cupuassu Butter (Theobroma grandiflorum Seed Butter) Post Treatment with Hair Dye. Journal of Cosmetics, Dermatological Sciences and Applications. 2013;03(03):40-44. doi:10.4236/jcdsa.2013.33a1006

Hajhashemi V, Rajabi P, Mardani M. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. Avicenna J Phytomed. 2019;9(6):499-504. doi:10.22038/AJP.2019.13463\

Lanzafame RJ, Blanche RR, Bodian AB, Chiacchierini RP, Fernandez-Obregon A, Kazmirek ER. The growth of human scalp hair mediated by visible red light laser and LED sources in males [published correction appears in Lasers Surg Med. 2014 Apr;46(4):373]. Lasers Surg Med. 2013;45(8):487-495. doi:10.1002/lsm.22173

Esmat SM, Hegazy RA, Gawdat HI, Abdel Hay RM, Allam RS, El Naggar R, et al. Low level light-minoxidil 5% combination versus either therapeutic modality alone in management of female patterned hair loss: a randomized controlled study. Lasers Surg Med. 2017 Nov;49(9):835–43.

Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, Eun HC, Kim KH. Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine. 2007 Aug;14(7-8):551-5. doi: 10.1016/j.phymed.2006.09.009. Epub 2006 Nov 7. PMID: 17092697.

Kim YY, Up No S, Kim MH, et al. Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model. Exp Dermatol. 2011;20(12):1015-1017. doi:10.1111/j.1600-0625.2011.01353.x

Fischer TW, Hipler UC, Elsner P. Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro. Int J Dermatol. 2007;46(1):27-35. doi:10.1111/j.1365-4632.2007.03119.x

Fischer TW, Herczeg-Lisztes E, Funk W, Zillikens D, Bíró T, Paus R. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro. Br J Dermatol. 2014 Nov;171(5):1031-43. doi: 10.1111/bjd.13114. Epub 2014 Oct 30. PMID: 24836650.

Dhurat R, Chitallia J, May TW, et al. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia. Skin Pharmacol Physiol. 2017;30(6):298-305. doi:10.1159/000481141

Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med. 2002 Apr;8(2):143-52. doi: 10.1089/acm.2002.8.143. Erratum in: J Altern Complement Med. 2006 Mar;12(2):199. PMID: 12006122.

Rossi A, Mari E, Scarno M, Garelli V, Maxia C, Scali E, Iorio A, Carlesimo M. Comparative effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1167-73. doi: 10.1177/039463201202500435. PMID: 23298508.

Wessagowit V, Tangjaturonrusamee C, Kootiratrakarn T, Bunnag T, Pimonrat T, Muangdang N, Pichai P. Treatment of male androgenetic alopecia with topical products containing Serenoa repens extract. Australas J Dermatol. 2016 Aug;57(3):e76-82. doi: 10.1111/ajd.12352. Epub 2015 May 25. PMID: 26010505.

Hibberts NA, Howell AE, Randall VA. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol. 1998;156:59–65. Kaufman KD. Androgens and alopecia. Mol Cell Endocrinol. 2002 Dec 30;198(1-2):89-95. doi: 10.1016/s0303-7207(02)00372-6. PMID: 12573818.

Merck & Co., Inc. Propecia® (finasteride) [package insert]. U.S. Food and Drug Administration website. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020788s024lbl.pdf. January 2014.

U.S. Food and Drug Administration: Center for Drug Evaluation and Research. Approval package for Propecia® (finasteride). https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/020788Orig1s020.pdf. March 11, 2011.

U.S. Food and Drug Administration: Center for Drug Evaluation and Research. Medical Review of Men's Rogaine Extra Strength 5% Topical Foam. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021812s000_MedR.pdf. January 18, 2006.

U.S. Food and Drug Administration: Center for Drug Evaluation and Research. Approval Package for Men's Rogaine Regular Strength and Women's Rogaine topical solutions, 2% minoxidil. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/019501s025.pdf. June 21, 2005.